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Acetyl Hexapeptide-8 (Argireline) is a 6-amino-acid peptide that mimics the N-terminus of SNAP-25 and inhibits the release of acetylcholine at the neuromuscular junction in muscle adjacent to dermis

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Other theories postulate that abnormalities in the enzymatic activity of aged retinal pigment epithelium (RPE) cells lead to the accumulation of metabolic byproducts