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Understanding these helps set realistic expectations

Persistent or worsening changes should be discussed with the prescribing clinician rather than accepted as an unavoidable part of treatment

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Route of administration and lifestyle fit For patients, the biggest differences lie in how these medications fit into their current lifestyle and life stage: Oral GLP1s require daily dosing Injectables are once weekly but require needles Roughly one in four adults has needle aversion, and oral options may open the door for patients previously unwilling or unable to use injectables

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