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The greater complexity of insulin treatment compared to oral medication, the association of lower persistence rates with type 2 diabetes treatment and the higher risk of hypoglycaemia experienced with insulin may have contributed to these findings [8]

Compared with JAK and TYK2 inhibitors, which exert potent downstream modulation, compounds such as baicalin and EGCG exhibit only partial JAK/STAT or PDE-like immunomodulatory activity, and crucially, they lack human-grade PK/PD validation [36, 37]

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however, their effects on OA incidence remain incompletely understood