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As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus

Statistical analysis The results are presented as mean SD for each group from at least three independent experiments

Clin Sci (Lond) 129, 10471060 (2015)

However, Ely Lilly has developed an oral version of the medication, Orforglipron, that the pharmaceutical company plans to submit to the Food & Drug Administration for approval by the end of the year, and for type 2 diabetes treatment in 2026

Diabetes Care 48 , 13861394 (2025)