The induction of RET/PTC, one of the primary oncogenes implicated in PTC, is linked to the pathogenic interaction between PTC and HT
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Angiogenesis Studies: Angiogenic potential investigated through multiple assays: HUVEC tube formation (network complexity), endothelial migration (cells/field), aortic ring sprouting (sprout length/number), VEGF/VEGFR2 expression (qPCR, Western blot), CAM assay (vessel density)
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The primary aim was to determine AOD9604s impact on body weight, adipose tissue mass, gene expression of 3-AR, and metabolic activity, as well as to evaluate whether the 3-AR is required for its effects [2]