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reported the absorption of dietary supplementation with functionalized selenite nanoparticles by the gastrointestinal epithelium through activating transport and passive diffusion pathways (Figure 7D) [32]

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SGLT2-I reduces oxidative stress by translocating Nrf2 to the nucleus and triggering Nrf2/ARE signaling, which lessens myocardial fibrosis by inhibiting collagen deposition through the traditional TGF-/Smad pathway [41]

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