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When the BBB is compromised by the disease process, UA can penetrate areas of the lesion and inhibit CNS pathology caused by free radical damage

While overt deficiencies in specific vitamins have cognitive effects (see Consequences of Select Micronutrient Deficiencies), correcting subclinical deficiencies through supplementation could possibly improve aspects of memory

fMRI has been used for more than two decades to assess neural function in specific regions of the brain as subjects perform a variety of tasks varying in difficulty and made more difficult by the overlay of scanner noise and physical restraint