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The SELECT cardiovascular outcomes trial published in 2023 added a cardiovascular benefit signal: semaglutide reduced major adverse cardiovascular events by 20% in overweight and obese patients with established cardiovascular disease, independent of diabetes status

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This is particularly important because body fat mass is associated with adverse health outcomes in obesity, whereas lean body mass is generally considered to be non-risk increasing and even protective

4, 5 Therefore, recent studies suggest that loss of H3K27me3 detected by immunohistochemistry may be helpful in the distinction of malignant peripheral nerve sheath tumors from other malignant spindle cell neoplasms