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Patients with depressive disorder in our study did not report suicidal attempts, which are associated with low 5-HIAA and cholesterol levels ( Figure 3 Omega-3 fatty acids, EPA, DHA, and their ratio play an important role in the pathophysiology of depressive disorders ( We found that omega-3-FA supplementation increases the urinary KYN/TRP ratio (representing IDO activity) after 12 weeks of supplementation and increases KYN levels after 6 and 12 weeks of omega-3-FA supplementation