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[62] [63] However, significant levels of intact IGF1 from oral consumption are not absorbed as they are digested by gastric enzymes

Unlike statins, which can cause myopathy through effects on muscle cell membranes and mitochondrial function, GLP-1 agonists do not have a known direct myotoxic mechanism

This is not a minor technical point

Mendelian randomization analysis also showed an inverse relationship between GLP-1 receptor expression and severe DR, indicating the potential of GLP-1RAs in reducing the risk of DR in type 2 diabetes patients (Zheng et al., 2023)

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