Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction
Preclinical research suggests DSIP influences sleep-wake cycles, circadian rhythm biology, and neurological signaling pathways
It also helps reduce inflammation, allowing for less downtime between workouts
Synergistic Anti-Aging and Firming Benefits 1) Mechanism: - Copper ions synergize with the tripeptide to stimulate collagen I/III synthesis, improving skin firmness
(2024) demonstrated that nitazoxanide and tizoxanide activates AMPK, inhibits STAT3 and Smad2/3 activation, collagen I expression and secretion leading to inhibition of liver fibrosis induced by carbon tetrachloride-induced and bile duct ligation in mice (Liu et al., 2024)