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The body has adapted

The STEP 2 trial [2] , which included participants with type 2 diabetes, showed slightly more modest but still substantial results, with 9.6% average weight loss compared to 3.4% with placebo

FDA has approved enlicitide (Lipfendra), the world's first oral PCSK9 inhibitor, marking a major milestone in the treatment of hypercholesterolemia

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Where tirzepatide differs is in the breadth of documented side effects from its longer time on market and larger real-world patient population