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The appetite suppression can be so effective that total caloric intake drops significantly, sometimes too significantly for adequate protein consumption

[11] Bescs et al. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012 Feb 1;42(2):99-117. doi: 10.2165/11596860-000000000-00000

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This changes the charge and shape of the peptide, reducing its ability to bind to GIP and GLP-1 receptors effectively

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