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positively associated with intestinal motility in patients with chronic constipation,71 while a 2021 study determined that 1 billion CFU/day of DE111 significantly improved gastrointestinal [GI] discomfort, including constipation and diarrhea, in people with occasional GI irregularities.72 The postbiotic Lactobacillus casei 327 (25mg) plays an important supporting role

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Patients with genetic predispositions favoring strong GLP-1 receptor function may experience more pronounced appetite suppression and weight loss with GLP-1 agonists, while others may see more modest benefits regardless of berberine or GLP-1 choice

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