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When an amylin analogue like cagrilintide is paired with a GLP-1/GIP receptor agonist, the complementary mechanisms appear to produce additive appetite suppression: cagrilintide slows gastric emptying through amylin receptor activation, while tirzepatide simultaneously boosts insulin secretion and reduces glucagon

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Participants were contacted by phone at week 4 to review product compliance, completion of the exercise behavior scale, concomitant therapies, adverse events and study requirements