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Metabolic syndrome, a combination of insulin resistance, hypertension and abdominal obesity, is a major risk factor for atherosclerotic heart disease and consequent myocardial infarction and heart failure.(136) Each of these defining features of the metabolic syndrome is mitigated by IF in rats and mice,(92, 93) and in models of type 2 (insulin resistance-mediated) diabetes.(63, 69, 137) An emerging literature indicates IF can also ameliorate many of the key features of the metabolic syndrome in humans by decreasing fasting glucose, fasting insulin, and insulin resistance.(8, 138) In most studies, IF regimens have been shown to reduce overall fat mass and visceral fat both of which have been linked to increased diabetes risk.(139) IF regimens ranging in duration from 8 to 24 weeks have consistently been found to decrease insulin resistance.(12, 115, 118, 119, 122, 123, 131, 132, 134, 140) In line with this, many, but not all,(7) large-scale observational studies have also shown a reduced risk of diabetes in participants following an IF eating pattern

9.&#009Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States

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Lachmandas, E

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