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Introduction Class B1 G-protein-coupled receptors (GPCRs) are activated by peptide hormones and neuropeptides that regulate essential physiological functions, including neuroprotection, bone turnover, cardiovascular tone, glycemic control, appetite, and energy balance (Bortolato et al., 2014)

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FLOW Trial Investigators List

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GLP-1 signals through receptors primarily in the pancreas, gut and brain to increase insulin signalling and reduce food intake 58

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