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2. Promote new blood vessel formation
Quick Takeaways Retatrutide (GLP-1/GIP/glucagon receptor agonist) shows up to 2428.7% body weight loss in Phase 2 & 3 trials, outperforming both Tirzepatide and Semaglutide but not yet FDA-approved Tirzepatide (GLP-1/GIP receptor agonist) delivers 2022.5% weight loss and is FDA-approved, beating Semaglutide by ~47% in head-to-head trials Semaglutide (GLP-1 receptor agonist) produces 1415% weight loss and remains the most widely prescribed, but is mechanistically inferior to dual and triple agonists All three share gastrointestinal side effects
Phosphorylated form of SQSTM1 physically interacted with KEAP1, an adaptor of the ubiquitin ligase complex for Nrf2, with high affinity (Ueno and Komatsu, 2017)
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