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In the Standards of Medical Care in Diabetes2021, the ADA recommend that for people with indications of high risk or established CKD either a sodium-glucose co-transporter-2 inhibitor (SGLT2i) or a glucagon-like peptide-1 receptor agonist (GLP-1 RA) be considered as a treatment option, independently of metformin use [15]

10.1186/S12933-021-01400-9/FIGURES/1 19 GiuglianoD.ScappaticcioL.LongoM.CarusoP.MaiorinoM

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Finally, they were examined using a high-resolution spinning disk confocal microscope, and fluorescence intensity and cell count were analyzed with ImageJ

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