SURMOUNT-5 also noted that weight loss was approximately 6% lower in men than women in both treatment groups but men on tirzepatide still do very well in absolute terms
As with any powerful therapy, there are questions we still need to answer: how these drugs behave over decades, how to protect lean mass at scale, how to dose safely in metabolically healthy individuals, how to separate genuine medical use from cosmetic hype, and how to ensure patients are not starved of protein or muscle
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