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The biological mechanisms driving postpartum weight retention differ from typical weight gain

10.6118/jmm.2015.21.2.93 30 LiY.FuH.WangH.LuoS.WangL.ChenJ.et al (2020a)

This advice derives from historical concerns that the reduced hepatic clearance of lactate in chronic liver disease may enhance the risk of lactic acidosis associated with metformin therapy [205,206], but the evidence supporting this warning is limited