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Vitamin C serums, used separately from any copper products, support collagen synthesis by serving as a cofactor for prolyl hydroxylase and lysyl hydroxylase enzymes

The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45

Ethics approval and consent to participate The medical ethics committee of the Maastricht University Medical Center+, the Netherlands approved the TearAD study (identifier: NL73600.068.20/METC 20033), and all participants provided written informed consent

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Weight fluctuates daily