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Rather than viewing complexity as an inherent liability, contemporary pharmacology increasingly recognizes that pleiotropic signaling can be therapeutically advantageous when appropriately modulated through dosing, bias, and patient stratification ( 7.1 Phoenixin: integrating metabolism, reproduction, and affect Phoenixin is a relatively recently described neuropeptide identified through bioinformatic analysis of conserved peptide sequences and expressed in both central and peripheral tissues

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