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Moreover, HA functions as an active targeting moiety to recognize the transmembrane glycoprotein CD44 receptor, which is overexpressed on surfaces of various tumor cells ( Modification with biomacromolecules Biomacromolecules, such as proteins, DNA, and peptides, have attracted so much attention in drug delivery because of their rich functions, biocompatibility, and stability in the body environment

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Experimental infection of cell lines has also shown that the activities of antioxidant enzymes may decrease over time 18,19 and that chemical stimulation from reactive oxygen species may even induce an upregulation of antioxidant enzymes in order to counteract oxidative stress 17

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The recombinant mutants K26A and D90A were subsequently purified (Supplementary Fig