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DOI: 10.137/journal.pone.0058299 41

GHK-Cu ( I III), , ,

422 SchieberM.ChandelN

134 The NLRP3 is also upregulated resulting from activated NF-B, and activates caspase 1 which induces cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig