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Given that excess free fatty acid (FFA) accumulation in hepatocytes and skeletal muscle is a major inducer of insulin resistance, several mediators of hepatic lipogenesis and skeletal muscle fatty acid oxidation have been identified as potential therapeutic targets

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A 1981 study showed that younger patients had less hepatotoxicity when exposed to the same levels of APAP acutely as older children and adults ( The reason underlying this age difference in toxicity remains incompletely understood

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