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But thats not it

For example a group of researchers [2] concluded that dietary glutathione (GSH) is not a major determinant of circulating glutathione (GSH), and it is not possible to increase circulating glutathione (GSH) to a clinically beneficial extent by the oral administration of a single dose of 3g of glutathione (GSH)

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

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