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Optogenetic activation of the neurons triggered immediate meal termination and reduced bout duration and frequency, while neural inhibition prolonged bout duration and increased food intake, showing that the neurons are necessary and sufficient for satiation

For patients with weight-management indications, monitoring for suicidality is recommended, as these medications carry warnings about suicidal thoughts and behaviors

High-street pharmacies can also dispense GLP-1 medications, but require a separately obtained prescription from a GP or private clinic

Pro: Lixisenatide is the only GLP analog that does not have a boxed warning about the risk of thyroid C-cell tumors

Nat Ment Health