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The patient inclusion criteria were as follows: no prior treatment with anthracyclines or iSGLT2, aged between 30 and 70 years, and a glomerular filtration rate (GFR) greater than 30 ml/min/1.73 m 2

Acknowledgements This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (R01DK119254)

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Nat Genet 46 (5): 478-81, 2014

Other potential challenges include anatomical barriers of the anterior eye that limit glutathione delivery to the lens and intracellular barriers within the lens that limit glutathione delivery to different lens regions