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The pivotal SURMOUNT and STEP clinical trial programs established the baseline results most providers reference today, and the difference between the two medications is consistent across studies
Baseline liver function tests (ALT, AST, bilirubin, ALP) may be considered, especially in patients with a history of liver disease
Most catalases are haemin-containing enzymes (i.e., their active sites consist of a ferric Fe 3+ ion complexed within a planar cyclic tetradentate porphyrin ligand [Milgrom, 1997]) made up of tetrameric protein subunits (see Figure 2)
This is the system that controls involuntary actions like heart rate and blood pressure
However, the study acknowledges its limitations, including its predominantly Caucasian patient population, potential selection bias, and the inability to determine the exact cause of elevated troponin levels for every patient
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