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Moreover, -MSH enhances DNA repair mechanisms by increasing the activity of base excision repair enzymes like OGG1 and APE-1, both of which are crucial for addressing oxidative DNA damage 17

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Furthermore, compelling evidence implicates this local, brainstem-derived GLP-1, rather than gut-derived GLP-1, as a principal modulator of physiological GLP-1R dependent signals that regulate appetite and body weight (Drucker and Asa, 1988