TARGETS OF PHARMACOTHERAPY IN THE MANAGEMENT OF OBESITY Novel insights provided by pathophysiology indicate the presence of a complex homeostatic system in which information about the energy reserve status and the meal quality and content is relayed from the periphery (gastrointestinal tract, pancreas, and adipose tissue) via specific orexigenic and anorexigenic peptides and hormones to the central nervous system (CNS)
For the experiment shown in Fig
FIGURE 2 3.1.1 BPTES BPTES is a specific GLS1 inhibitor that forms a stable inactive tetrameric form of KGA (Katt et al., 2012
15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more
Future research should aim to expand the scope of this work by exploring a wider range of solvent systems, including ternary and more complex mixtures, to further validate the models generalizability
