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J Am Coll Cardiol 71(1):6984 Pasquali R, Casanueva F, Haluzik M et al (2020) European society of endocrinology clinical practice guideline: endocrine work-up in obesity

It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

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[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Shukla M., Govitrapong P., Boontem P., Reiter R.J., Satayavivad J

For more on this topic, the peptide reconstitution guide covers water types in detail