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Age-related factors Older patients may have thinner skin and less subcutaneous fat, potentially requiring shorter and thinner needles to prevent intramuscular injections

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What they found: Erectile response in 80 % of subjects in the Melanotan II group vs 20 % placebo Mean time to erection: 45 minutes Mean duration of erection: 90 minutes Subjectively satisfactory penetrative capability in 70 % Nausea in 50 % of subjects Why it matters: This was the first clinical demonstration of the melanocortin mechanism for erectile function