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Clinical and Translational Report LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept Graphical abstract Highlights dLY3437943 has triple agonist activity at the glucagon, GIP, and GLP-1 receptors dLY3437943 caused greater body weight loss in obese mice than tirzepatide dLY3437943 increased energy expenditure through glucagon receptor activation dSafety and tolerability of LY3437943 were similar to other incretin-based drugs Authors Tamer Coskun, Shweta Urva, William C

and the fibrous outer layer (bran), which contains soluble and insoluble fiber, are removed