powder semaglutide storage Arg34GLP-1(9-37)(H5)(Lyophilized powder) Semaglutide — Research Peptide (Lyophilised,

Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)

BMC Endocrine Disorders, 18(2), 89-95

Pharmacopsychiatry 29 , 2326 (1996)

Important context: Discontinuation rates were highly correlated with baseline BMI

Weight-related comorbidities are health conditions that are impacted by or influence body weight