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Nevertheless, as the phenotypes caused by most yeast prions result from loss-of-function of a protein, which already performs a distinct molecular role in its native state, the functional character of the yeast prions has been contested and an alternative view presents them as analogous to human amyloidosis and other prion diseases (Wickner et al., 2011)

10.1038/s41556-022-00949-1 13 ClaraA.MartaK.PaulaM.-S.Lpez-PoloV.TorresT.PuigS.et al (2024)

Contributions of the GSH and Trx pathways in supporting RNR Although growth differences have not been reported between having only a GSH- or only a Trx-pathway (Holmgren, 1977

This should be taken into account in future research