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In selecting a third agent added to metformin and DPP4 inhibitor, the ADA/EASD guidelines recommend selecting one of the agents among sulfonylurea, thiazolidinedione, SGLT-2 inhibitor or insulin, whereas other agents, including -glucosidase inhibitor, are generally not favored because of their modest efficacy and frequency of administration [2]

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The general rule, all peptides expire , and proper storage extends their useful life significantly

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