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if this risk was carried over millions of users, those affected could end up being a sizable group of patients. 2 The commentary author also highlighted that the study focused on patients with diabetes who were older than 66 years and observed these patients for up to three years

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This patient was also receiving several other nephrotoxic medications (ie, furosemide, vancomycin, and piperacillin-tazobactam), which may have prevented the patients kidneys from properly clearing methotrexate

If the patient is known to have low potassium or heart rhythm issues, monitor electrolytes