The size of the benefit depends on accurate dosing, careful titration, and body-composition tracking, which is exactly where supervised care separates from a mail-order injection
In discussing these drugs, there is a lot on our plate
Why we cap deficits at 15% We recommend a more sustainable weight-loss rate of around 0.5-1kg per week, as research suggests that losing weight faster than this can increase muscle and bone loss
For patients with diabetes, the side effects, injection demand, and cost of these drugs should be weighed against the effects of improving blood glucose and losing weight
Clinical studies Compared with the considerable amount of pre-clinical and mechanistic research reported above, we identified few clinical studies of GLP-1RAs for substance-use disorders (Table 2): three for alcohol 111,112,113 , one for cannabis 114 , two for cocaine 115,116 and two for nicotine 117,118 , while no article about opiates or amphetamines was retrieved