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SAM is the methyl donor for DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) that maintain methylation patterns at CpG sites, and for the histone methyltransferases (EZH2, SETD2, NSD2) that methylate histones to regulate chromatin state and gene expression

Folate can also help prevent the buildup of plaque in your arteries, which can narrow them and raise your blood pressure

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