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108 The strongest evidence that demonstrates GLP-1s ability to directly inhibit glucagon secretion comes from the observation that the ability of T1D patients to secrete glucagon is suppressed after GLP-1 infusion and glycaemic control is improved
Olsen BR, Reginato AM, Wang W
They used a mouse model of diet-induced obesity and combined metabolomic analyses in BAT and other tissues with stable-isotope tracer studies to answer this question
Conclusion The GLP-1 hormone is recognized as an effective target for the treatment of T2DM due to its multifaceted role in glucose regulation
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