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A highly selective small molecule inhibitor, Vemurafenib/Zelboraf (PLX4720/PLX4032), against cells that harbor the most common mutation in melanoma, mutated BRAF V600E , was initially reported to have therapeutic effects in patients with advanced melanoma but its effectiveness was marred by patient relapse within 812 months (138141)

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Diagnostic and therapeutic modalities must be carefully considered as these lesions encompass the spectrum of clinical pathology, ranging from benign to malignant

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