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Rifampicin was chosen for its ability to penetrate mammalian cells 7

The closest published human safety data is for CB4211 , a synthetic MOTS-c analog that completed a Phase 1 trial and was reported as well tolerated

In recent years, the drugs have transitioned from being solely for type 2 diabetes treatment to increasing use as weight loss drugs, with Novo Nordisks Wegovy and Eli Lillys Zepbound being developed specifically for that purpose

(2016), Indian Dermatology Online Journal , reviewed glutathione's proposed mechanisms and use in skin lightening, noting that while plausible biologically, larger and longer-term trials are still needed