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This appetite modulation occurs through both peripheral mechanisms (slowed gastric emptying) and central mechanisms (direct effects on hypothalamic appetite centers)

Prolactin, another hormone found in breast milk, is thought to help nutrient absorption in the intestines of infants [10]

The mechanism appears to involve stimulation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activity, leading to accelerated triglyceride hydrolysis and increased free fatty acid release

[27] found that the deletion of add resulted in a reduced cell density due to the down-regulated tricarboxylic acid cycle

This effect compounds over months