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The location of the PSPH gene on chromosome 7p11.2 is in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, WBS (also called Williams syndrome, WS)

Additionally, there is an increase in RBC-MPs [413]

The impact of IGF-1 LR3 on human-derived tissue models and preclinical studies reveals significant anabolic and regenerative effects, especially in muscle and connective tissue systems

Cell Host Microbe 30, 289300

These changes were even more pronounced in individuals with HFrEF, 46 where increased cardiac expression of the fission regulatory protein, dynamin-related protein-1, and decreased mitochondrial complex IV activity were also observed