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The greater melanin in the epidermis, which screens twofold as much UV light as that in Caucasians' epidermis, is principally responsible for the lower incidence of skin malignancies in darker-skinned races

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In fact, a B12 deficiency can sometimes lead to weight loss due to reduced appetite

The extended conformation assumed by the enzyme-bound inhibitor as well as the strategic interactions between inhibitor and protein, closely resemble those observed for the physiological substrate, reduced glutathione bound at the active site of class Mu glutathione S-transferase 3-3

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