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Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions

Clinical trial results discussed in this article - STEP 1 (14.9% average body weight loss with semaglutide), SURMOUNT-1 (20.9% average body weight loss with tirzepatide), and SELECT (20% reduced risk of major cardiovascular events with FDA-approved Wegovy in a specific patient population) - relate to studied active ingredients and specific FDA-approved formulations in controlled trial populations and should not be interpreted as guaranteed outcomes for any individual patient or compounded formulation

Powe, co-director of the Diabetes in Pregnancy Program at Massachusetts General Hospital and senior author of the study

Instead of acting on the brain, it works in the gut by blocking the absorption of dietary fat