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A recent study in colon cancer cells by Pathi et al, 2012 demonstrated that aspirin caused caspase-dependent proteolysis of Sp1, Sp3 and Sp4 (specificity protein) transcription factors, which was associated with downregulation of several Sp-regulated genes involved in cell survival, proliferation and angiogenesis
doi: 10.1152/physiolgenomics.00081.2016 5 AlbillosA.de GottardiA.RescignoM
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