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Endotoxins activate specific membrane receptors termed Toll-like receptors that are members of a class of pro-inflammatory receptors hat recognize pro-inflammatory molecules termed pattern-associated molecular patterns or PAMPS that in turn can activate genes that initiate inflammatory cascades in the host [49, 65]

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In vivo experiments have validated Onenas approach, proving that disruption of a DSIPs activity with a neutralizing antibody reprograms cancer cells to accept environmental cell death signals from BMPs and Activins

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is supported by the US National Institutes of Health (grant nos